Nhân sự

Hồ Việt Đức

Hồ Việt Đức

Phó Giáo sư,  Tiến sĩ

Khoa Dược Giảng viên

Lĩnh vực nghiên cứu

- Chiết xuất, phân lập, xác định cấu trúc, thử hoạt tính sinh học các hợp chất tự nhiên

- Tổng hợp, bán tổng hợp các chất có hoạt tính sinh học

- Nghiên cứu tinh dầu, hương liệu

- Hóa tính toán, mô phỏng

Đề tài NCKH chủ trì/tham gia

1. Nghiên cứu thành phần hóa học và hoạt tính gây độc tế bào ung thư của cây Cà mà vòi to (Buxus latistyla)- Đại học Huế - Mã số: DHH2021-04-152

2. Nghiên cứu thành phần hóa học và hoạt tính gây độc tế bào của cây cơm rượu (Glycomis sp.) thuộc họ Cam (Rutaceae) ở Việt Nam- Đại học Huế - Mã số: DHH2019-04-96

3. Nghiên cứu các hợp chất có tác dụng gây độc tế bào ung thư từ cây tỏi rừng (Aspidistra sp.) ở Việt Nam- Đại học Huế - Mã số: DHH2019-04-101

4. Nghiên cứu thành phần hóa học và hoạt tính gây độc tế bào ung thư của cây bù dẻ râu (UVARIA FAUVELIANA (FIN.& GAGNEP.) – Họ NA (ANNONACEAE)- Đại học Huế - Mã số: DHH2014-04-35

5. Nghiên cứu thành phần hóa học và tác dụng ức chế Acetylcholinesterase của một số loài thuộc chi Hippeastrum Herb, ở Việt Nam- Cấp Bộ - Mã số: B2018-DHH-63

6. Nghiên cứu sàng lọc các hợp chất có hoạt tính kháng tế bào ung thư từ một số loài thực vật thuộc chi Anodendron, họ Trúc đào (Apocynaceae) ở Việt Nam- Cấp Bộ - Mã số: B2017-DHH-50

7. Nghiên cứu tác dụng ức chế phát triển tế bào ung thư từ các loài thuộc chi Hedyotis thuộc họ cà phê (Rubiaceae) có ở Việt Nam- Cấp Bộ - Mã số: B2015-DHH-126

8. Nghiên cứu phát hiện các chất kháng ung thư và kháng viêm tiềm năng từ chi Gymnosporia ở Việt Nam- Nafosted - Mã số: 108.05-2023.03

9. Đánh giá hoạt tính kháng ung thư và kháng viêm của các hợp chất phân lập từ các loài thuộc chi Chisocheton ở Việt Nam- Nafosted - Mã số: 104-01-2017.09

Công bố quốc tế

1. Hoang, H. N. T., Vo, H. Q., Nguyen, L. T. K., Thi Tran, L. T., Nguyen, H. T., Pham, T. V., Le, H. T., Canh Le, C. V., Nguyen, B. C., & Ho, D. V. (2024). Conamonin A and dihydrochalcones from the whole plants of Conamomum rubidum (Lamxay & N.S.Lý) Škorničk. & A.D. Poulsen showing anti-inflammatory and cytotoxic activities. Natural Product Research, 39(10), 2804–2809. https://doi.org/10.1080/14786419.2024.2315595

2. Nguyen, T. K., Thuy Thi Tran, L., Ho Viet, D., Thai, P. H., Ha, T. P., Ty, P. V., Duc, L. P., Ton That Huu, D., & Cuong, L. C. V. (2023). Xanthine oxidase, α-glucosidase and α-amylase inhibitory activities of the essential oil from Piper lolot: In vitro and in silico studies. Heliyon, 9(8), e19148. https://doi.org/10.1016/j.heliyon.2023.e19148

3. Le, N. T., Nguyen, T. P. D., Ho, D. V., Phung, H. T., & Nguyen, H. T. (2023). Green solvents-based rutin extraction from Sophora japonica L. Journal of Applied Research on Medicinal and Aromatic Plants, 36, 100508. https://doi.org/10.1016/j.jarmap.2023.100508

4. Nguyen, T. K., Thi Tran, L. T., Truong Tan, T., Pham, P. T. V., Nguyen, L. T. K., Nguyen, H. T., Ho, D. V., & Tran, M. H. (2023). Isolation, structural elucidation, and cytotoxic activity investigation of novel styryl-lactone derivatives from Goniothalamus elegans : in vitro and in silico studies. RSC Advances, 13(26), 17587–17594. https://doi.org/10.1039/d3ra02646a

5. Hoang, H. N. T., Vo, H. Q., Tran, L. T. T., Nguyen, H. T., & Ho, D. V. (2023). Conarubins A–D: Four Monoterpene–Chalcone Conjugates from Conamomum rubidum and Their Anti-inflammatory and Cytotoxic Activities. The Journal of Organic Chemistry, 88(21), 15318–15325. https://doi.org/10.1021/acs.joc.3c01825

6. Nguyen, L. T. K., Vo, H. Q., Hoang, H. N. T., Tran, T. V. A., Minh Nguyen, H., Pham, T. V., Ngo, H. P. T., Pham, T., & Ho, D. V. (2023). Structure revision and absolute configuration of 5,7- diepi-2α -hydroxyoplopanone and anti-osteoporotic activities of sesquiterpenoids from the rhizomes of Homalomena pendula. Natural Product Research, 38(14), 2453–2462. https://doi.org/10.1080/14786419.2023.2180505

7. Bich Thi Le, H., Ho, D. V., Minh Nguyen, H., Tran, V. A. T., & Nguyen, H. T. (2023). Aspidiatas C and D, two new spirostanol saponins from Aspidistra triradiata and their cytotoxic activities. Natural Product Research, 38(5), 829–837. https://doi.org/10.1080/14786419.2023.2204432

8. Doan, T. Q., Dinh, D., Nam Tran, T., Quynh Dinh Nguyen, P., Bao Hoai Nguyen, C., Trong Le, N., Vo, H. Q., Ho, D. V., Tuan, A. L., Nguyen, H. T., & Ogunwande, I. A. (2023). Chemical composition and acetylcholinesterase inhibitory activity of essential oil from the leaves ofMitrephora poilaneiWeeras. & R.M.K. Saunders. Natural Product Research, 38(11), 1882–1886. https://doi.org/10.1080/14786419.2023.2227989

9. Nguyen, L. T. K., Doan, T. Q., Nguyen, P. Q. D., Nguyen, C. B. H., Tran, L. T. T., Tran, T. V. A., Nguyen, H. T., & Ho, D. V. (2023). Phytochemical Composition and Bioactivities of Essential Oils from Rhizomes of Homalomena pendula and Homalomena cochinchinensis. Natural Product Communications, 18(5). https://doi.org/10.1177/1934578x231175263

10. Nguyen, L. T. K., Nguyen, P. Q. D., Doan, N. A. T., Nguyen, C. B. H., Doan, T. Q., Tran, L. T. T., Nguyen, H. T., & Ho, D. V. (2023). Volatile Components and Biological Activities of n -Hexane Extract From Rhizomes of Homalomena cochinchinensis. Natural Product Communications, 18(4). https://doi.org/10.1177/1934578x231168481

11. Le, H. B. T., Tran, V. A. T., Nguyen, H. M., Nguyen, L. T. K., Ho, D. V., & Nguyen, H. T. (2023). Aspidiata E, a New Spirostanol Saponin From Aspidistra triradiata and its Cytotoxic Activity. Natural Product Communications, 18(6). https://doi.org/10.1177/1934578x231179412

12. Ho, D. V., Hoang, H. N. T., Nguyen, N. H., Do, H. B., Vo, H. Q., Le, A. T., Le, T. Q., & Pham, T. V. (2023). GC-MS Characterization, in Vitro Antioxidant and Anti-Inflammatory Activities of Essential oil from the Leaves of Litsea balansae Lecomte. Natural Product Communications, 18(11). https://doi.org/10.1177/1934578x231214159

13. Nguyen, T. K., Le, Y. T., Ho, D. V., Nguyen, H. T., & Tran, L. T. T. (2023). Xanthine Oxidase Inhibitory Activity of Fatty Acids From Hedyotis pilulifera : In Vitro and In Silico Studies. Natural Product Communications, 18(8). https://doi.org/10.1177/1934578x231192161

14. Le, N. T., Nguyen, T. P. D., Ho, D. V., Phung, H. T., & Nguyen, H. T. (2023). A green method to extract rutin from Sophora japonica L. MethodsX, 11, 102479. https://doi.org/10.1016/j.mex.2023.102479

15. Pham, T. V., Ho, D. V., Tuan Le, A., Duy Ngo, Y., Thanh Thi Dang, N., Quoc Le, T., & Nguyen, B. C. (2023). Chemical composition and biological activities of essential oil from Grewia bulot leaves. Natural Product Research, 38(23), 4106–4112. https://doi.org/10.1080/14786419.2023.2275739

16. Phuong, D. T. L., Cong, N. T., Phuong, N. V., Hue, N. T., Vuong, N. Q., Lien, N. T. P., Ho, D. V., Tuan, N. L., Nghia, N. T., Tuyen, V. T. T., Hang, N. T., & Thanh, L. (2023). Chemical Constituents, Cytotoxicity, and Molecular Docking Studies of Tetragonula iridipennis Propolis. Natural Product Communications, 18(12). https://doi.org/10.1177/1934578x231219088

17. Quan, N. H., Thi Thuy Hang, P., Thi Thu Nga, N., Duc, H. V., Hue, V. T., Thuong, S. D., Thanh, L. N., & Mau, C. H. (2023). Chemical constituents and biological activities of the leaves of Adinandra megaphylla. Phytochemistry Letters, 56, 19–23. https://doi.org/10.1016/j.phytol.2023.06.002

18. Pham, T. V., Ho, D. V., Le, A. T., Ngo, Y. D., Dang, N. T. T., Le, T. Q., & Nguyen, B. C. (2023). Volatile Organic Compounds and Antioxidant, Cytotoxic Activities of Extracts from the Leaves of Grewia bulot Indonesian Journal of Chemistry, 23(5), 1394. https://doi.org/10.22146/ijc.84619

19. Nguyen, L. T. K., Nguyen, P. Q. D., Nguyen, C. B. H., Nguyen, H. T., Van Anh Tran, T., Mai, T.-T., Tran, T.-S., & Ho, D. V. (2022). Sesquiterpenoids from the rhizomes of Homalomena pendula (Blume) Bakh.f showing acetylcholinesterase inhibitory activity: in vitro and in silico studies. Chemical Papers, 77(3), 1573–1581. https://doi.org/10.1007/s11696-022-02573-7

20. Tuan, D. Q., Dinh, D., Tran, T. N., Pham, T. V., Ho, D. V., Le, N. T., Le, A. T., & Nguyen, H. T. (2022). Chemical Composition of Essential Oil from the Zingiber monophyllum (Zingiberaceae) from Vietnam. Journal of Essential Oil Bearing Plants, 25(5), 987–993. https://doi.org/10.1080/0972060x.2022.2132835

21. Ton That Huu, D., Phuong, H. T., Diem Tran, P. T., Souvannalath, B., Trung, H. L., Ho, D. V., & Viet, C. L. C. (2022). Secondary Metabolites From the Grasshopper-Derived Entomopathogenic Fungus Aspergillus Tamarii NL3 and Their Biological Activities. Natural Product Communications, 17(12). https://doi.org/10.1177/1934578x221141548

22. Nguyen, L. T. K., Hoang, H. N. T., Tran, T. V. A., Nguyen, H. T., & Ho, D. V. (2022). Homalolides C-D, two new sesquiterpenoids from the rhizomes of Homalomena pendula. Natural Product Research, 38(1), 60–67. https://doi.org/10.1080/14786419.2022.2103557

23. Nguyen, L. T. K., Hoang, H. N. T., Do, T. T., Tran, T. V. A., Nguyen, H. T., & Ho, D. V. (2022). Sesquiterpenoids from the rhizomes of Homalomena pendula and their anti-inflammatory activities. Natural Product Research, 37(15), 2559–2567. https://doi.org/10.1080/14786419.2022.2056182

24. Bich Thi Le, H., Viet Ho, D., Minh Nguyen, H., Tuan Le, A., Tran, T. V. A., & Nguyen, H. T. (2022). A new spirostanol steroid and a new spirostanol steroidal saponin from Aspidistra triradiata and their cytotoxic activities. Natural Product Research, 37(21), 3595–3604. https://doi.org/10.1080/14786419.2022.2095635

25. Tran, L. T. T., Le, T. N., Ho, D. V., Nguyen, T. H., Pham, V. P. T., Van Pham, K. T., Nguyen, T. K., & Tran, M. H. (2022). Virtual Screening and in Vitro Evaluation to Identify a Potential Xanthine Oxidase Inhibitor Isolated from Vietnamese Uvaria cordata. Natural Product Communications, 17(2). https://doi.org/10.1177/1934578x221080339

26. Tran, L. T. T., Dang, N. Y. T., Nguyen Le, N. T., Nguyen, H. T., Ho, D. V., Do, T. T., Tran, M. H., Nguyen, T. K., & Pham, P. T. V. (2022). In Silico and in Vitro Evaluation of Alkaloids from Goniothalamus elegans Ast. for Breast Cancer Treatment. Natural Product Communications, 17(3). https://doi.org/10.1177/1934578x221088110

27. Nguyen, T. K., Tran, T. H., Nguyen, K., Ho, D. V., Nguyen, H. T., & Tran, L. T. T. (2022). Deep Learning Model to Identify Potential Acetylcholinesterase Inhibitors: A Case Study of Isolated Compounds From Pongamia pinnata (L.) Pierre. Natural Product Communications, 17(7). https://doi.org/10.1177/1934578x221117310

28. Witayateeraporn, W., Nguyen, H. M., Ho, D. V., Nguyen, H. T., Chanvorachote, P., Vinayanuwattikun, C., & Pongrakhananon, V. (2022). Aspiletrein A Induces Apoptosis Cell Death via Increasing Reactive Oxygen Species Generation and AMPK Activation in Non-Small-Cell Lung Cancer Cells. International Journal of Molecular Sciences, 23(16), 9258. https://doi.org/10.3390/ijms23169258

29. Tuan, D. Q., Dien, D., Pham, T. V., Le, T. Q., Ho, D. V., Nhan, L. T., Anh, L. T., Huong, P. T., & Hoai, N. T. (2021). Chemical Composition of Essential Oil from the Rhizomes and Leaves ofNewmania sontraensisH.Ð.Trân, Luu & Škornick (Zingiberaceae) from Vietnam. Journal of Essential Oil Bearing Plants, 24(6), 1260–1268. https://doi.org/10.1080/0972060x.2022.2026253

30. Viet Cuong, L. C., Nhi, N. P. K., Ha, T. P., Anh, L. T., Dat, T. T. H., Oanh, P. T. T., Phuong, N. T. M., Thu, V. T. K., Duc, H. V., & Anh, H. L. T. (2021). A new steroidal saponin from the aerial parts of Solanum torvum. Natural Product Research, 36(19), 4892–4897. https://doi.org/10.1080/14786419.2021.1908282

31. Ho, D. V., Nguyen, H. T., Vu, T.-Y., Pham, T. V., & Nguyen, H. M. (2021). Antioxidant Activity of a New Xanthone Derivative from Aspidistra Letreae: In Vitro and In Silico Studies. Chemistry &Amp; Biodiversity, 18(4). Portico. https://doi.org/10.1002/cbdv.202001008

32. Oanh, V. T. K., Ha, N. T. T., Duc, H. V., Thuc, D. N., Hang, N. T. M., & Thanh, L. N. (2021). New triterpene and nor-diterpene derivatives from the leaves of Adinandra poilanei. Phytochemistry Letters, 46, 110–113. https://doi.org/10.1016/j.phytol.2021.10.003

33. Nguyen, K. V., Nguyen, T. O. T., Ho, D. V., Heinämäki, J., Raal, A., & Nguyen, H. T. (2021). In Vitro Acetylcholinesterase Inhibitory and Antioxidant Activity of Alphonsea tonkinensis A.DC. Natural Product Communications, 16(9). https://doi.org/10.1177/1934578x211042134

34. Nguyen, H. M., Nguyen, H. T., Seephan, S., Do, H. B., Nguyen, H. T., Ho, D. V., & Pongrakhananon, V. (2021). Antitumor activities of Aspiletrein A, a steroidal saponin from Aspidistra letreae, on non-small cell lung cancer cells. BMC Complementary Medicine and Therapies, 21(1). https://doi.org/10.1186/s12906-021-03262-w

35. Trong Le, N., Viet Ho, D., Quoc Doan, T., Tuan Le, A., Raal, A., Usai, D., Sanna, G., Carta, A., Rappelli, P., Diaz, N., Cappuccinelli, P., Zanetti, S., Thi Nguyen, H., & Donadu, M. G. (2020). Biological Activities of Essential Oils from Leaves of Paramignya trimera (Oliv.) Guillaum and Limnocitrus littoralis (Miq.) Swingle. Antibiotics, 9(4), 207. https://doi.org/10.3390/antibiotics9040207

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37. Trong Le, N., Viet Ho, D., Quoc Doan, T., Tuan Le, A., Raal, A., Usai, D., Madeddu, S., Marchetti, M., Usai, M., Rappelli, P., Diaz, N., Zanetti, S., Thi Nguyen, H., Cappuccinelli, P., & Donadu, M. G. (2020). In Vitro Antimicrobial Activity of Essential Oil Extracted from Leaves of Leoheo domatiophorus Chaowasku, D.T. Ngo and H.T. Le in Vietnam. Plants, 9(4), 453. https://doi.org/10.3390/plants9040453

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39. Hoang, T. H. X., Ho, D. V., Van Phan, K., Le, Q. V., Raal, A., & Nguyen, H. T. (2020). Effects of Hippeastrum reticulatum on memory, spatial learning and object recognition in a scopolamine-induced animal model of Alzheimer’s disease. Pharmaceutical Biology, 58(1), 1107–1113. https://doi.org/10.1080/13880209.2020.1841810

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52. Viet Nguyen, K., Laidmäe, I., Kogermann, K., Lust, A., Meos, A., Viet Ho, D., Raal, A., Heinämäki, J., & Thi Nguyen, H. (2019). Preformulation Study of Electrospun Haemanthamine-Loaded Amphiphilic Nanofibers Intended for a Solid Template for Self-Assembled Liposomes. Pharmaceutics, 11(10), 499. https://doi.org/10.3390/pharmaceutics11100499

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54. Nguyen, H. T., Doan, H. T., Ho, D. V., Pham, K. T., Raal, A., & Morita, H. (2018). Huperphlegmines A and B, two novel Lycopodium alkaloids with an unprecedented skeleton from Huperzia phlegmaria, and their acetylcholinesterase inhibitory activities. Fitoterapia, 129, 267–271. https://doi.org/10.1016/j.fitote.2018.07.016

55. Nguyen, H. T., Tran, L. T. T., Ho, D. V., Le, D. V., Raal, A., & Morita, H. (2018). Pogostemins A-C, three new cytotoxic meroterpenoids from Pogostemon auricularius. Fitoterapia, 130, 100–104. https://doi.org/10.1016/j.fitote.2018.08.015

56. Tran, L. T. T., Ho, D. V., Le, D. V., Hung, T. M., Nguyen, H. T., & Raal, A. (2018). Three new phloroglucinol derivatives from the aerial parts of Pogostemon auricularius and their cytotoxic activity. Phytochemistry Letters, 28, 88–92. https://doi.org/10.1016/j.phytol.2018.09.016

57. Nguyen, H. T., Ho, D. V., Nguyen, P. D. Q., Vo, H. Q., Do, T. T., & Raal, A. (2018). Cytotoxic Evaluation of Compounds Isolated from the Aerial Parts of Hedyotis pilulifera and Methanol Extract of Inonotus obliquus. Natural Product Communications, 13(8). https://doi.org/10.1177/1934578x1801300805

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